NOVA1 directs PTBP1 to hTERT pre-mRNA and promotes telomerase activity in cancer cells

Alternative splicing is dysregulated in cancer cells, driving the production of isoforms that allow tumor cells to survive and continuously proliferate. Part of the reactivation of telomerase involves the splicing of hTERT transcripts to produce full-length (FL) TERT. Very few splicing factors to da...

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Bibliografiska uppgifter
I publikationen:Oncogene
Huvudupphovsmän: Sayed, Mohammed E., Yuan, Laura, Robin, Jerome D., Tedone, Enzo, Batten, Kimberly, Dahlson, Nicole, Wright, Woodring E., Shay, Jerry W., Ludlow, Andrew T.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6474811/
https://ncbi.nlm.nih.gov/pubmed/30568224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0639-8
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