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NOVA1 directs PTBP1 to hTERT pre-mRNA and promotes telomerase activity in cancer cells
Alternative splicing is dysregulated in cancer cells, driving the production of isoforms that allow tumor cells to survive and continuously proliferate. Part of the reactivation of telomerase involves the splicing of hTERT transcripts to produce full-length (FL) TERT. Very few splicing factors to da...
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| Publicado no: | Oncogene |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6474811/ https://ncbi.nlm.nih.gov/pubmed/30568224 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0639-8 |
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