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NOVA1 directs PTBP1 to hTERT pre-mRNA and promotes telomerase activity in cancer cells
Alternative splicing is dysregulated in cancer cells, driving the production of isoforms that allow tumor cells to survive and continuously proliferate. Part of the reactivation of telomerase involves the splicing of hTERT transcripts to produce full-length (FL) TERT. Very few splicing factors to da...
Enregistré dans:
| Publié dans: | Oncogene |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6474811/ https://ncbi.nlm.nih.gov/pubmed/30568224 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0639-8 |
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