Bacterial persistence promotes the evolution of antibiotic resistance by increasing survival and mutation rates

Persisters are transiently antibiotic-tolerant cells that complicate the treatment of bacterial infections. Both theory and experiments have suggested that persisters facilitate genetic resistance by constituting an evolutionary reservoir of viable cells. Here, we provide evidence for a strong posit...

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Библиографические подробности
Опубликовано в: :ISME J
Главные авторы: Windels, Etthel Martha, Michiels, Joran Elie, Fauvart, Maarten, Wenseleers, Tom, Van den Bergh, Bram, Michiels, Jan
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6474225/
https://ncbi.nlm.nih.gov/pubmed/30647458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41396-019-0344-9
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