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A high level of cyclooxygenase-2 inhibitor selectivity is associated with a reduced interference of platelet cyclooxygenase-1 inactivation by aspirin

Both nonsteroidal anti-inflammatory drugs, such as ibuprofen, and the prototypical selective cyclooxygenase (Cox)-2 inhibitors DuP-697 and NS-398 block the inhibition of Cox-1 by aspirin in vitro. However, clinical studies have shown that the Cox-2 selective drugs (or coxibs) rofecoxib and etoricoxi...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Ouellet, Marc, Riendeau, Denis, Percival, M. David
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2001
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC64725/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11717412/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.251543298
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