L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction

L-amino acid transporters (LATs) play key roles in human physiology and are implicated in several human pathologies. LATs are asymmetric amino acid exchangers where the low apparent affinity cytoplasmic side controls the exchange of substrates with high apparent affinity on the extracellular side. H...

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Pubblicato in:Nat Commun
Autori principali: Errasti-Murugarren, Ekaitz, Fort, Joana, Bartoccioni, Paola, Díaz, Lucía, Pardon, Els, Carpena, Xavier, Espino-Guarch, Meritxell, Zorzano, Antonio, Ziegler, Christine, Steyaert, Jan, Fernández-Recio, Juan, Fita, Ignacio, Palacín, Manuel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6472337/
https://ncbi.nlm.nih.gov/pubmed/31000719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09837-z
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