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Decreased Protein Kinase C-β Type II Associated with the Prominent Endotoxin Exhaustion in the Macrophage of FcGRIIb−/− Lupus Prone Mice is Revealed by Phosphoproteomic Analysis

Dysfunction of FcGRIIb, the only inhibitory receptor of the FcGR family, is commonly found in the Asian population and is possibly responsible for the extreme endotoxin exhaustion in lupus. Here, the mechanisms of prominent endotoxin (LPS) tolerance in FcGRIIb−/− mice were explored on bone marrow-de...

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Dettagli Bibliografici
Pubblicato in:Int J Mol Sci
Autori principali: Ondee, Thunnicha, Jaroonwitchawan, Thiranut, Pisitkun, Trairak, Gillen, Joseph, Nita-Lazar, Aleksandra, Leelahavanichkul, Asada, Somparn, Poorichaya
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6472018/
https://ncbi.nlm.nih.gov/pubmed/30889825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20061354
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