TCR activation mimics CD127(low)PD-1(high) phenotype and functional alterations of T lymphocytes from septic shock patients

BACKGROUND: Sepsis is the leading cause of mortality for critically ill patients worldwide. Patients develop T lymphocyte dysfunctions leading to T-cell exhaustion associated with increased risk of death. As interleukin-7 (IL-7) is currently tested in clinical trials to reverse these dysfunctions, i...

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Bibliographische Detailangaben
Veröffentlicht in:Crit Care
Hauptverfasser: Mouillaux, Julie, Allam, Camille, Gossez, Morgane, Uberti, Thomas, Delwarde, Benjamin, Hayman, Jack, Rimmelé, Thomas, Textoris, Julien, Monneret, Guillaume, Peronnet, Estelle, Venet, Fabienne
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6472012/
https://ncbi.nlm.nih.gov/pubmed/30995946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13054-018-2305-5
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