Role of SIRT-3, p-mTOR and HIF-1α in Hepatocellular Carcinoma Patients Affected by Metabolic Dysfunctions and in Chronic Treatment with Metformin

The incidence of hepatocellular carcinoma deriving from metabolic dysfunctions has increased in the last years. Sirtuin- (SIRT-3), phospho-mammalian target of rapamycin (p-mTOR) and hypoxia-inducible factor- (HIF-1α) are involved in metabolism and cancer. However, their role in hepatocellular carcin...

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Publicado no:Int J Mol Sci
Main Authors: De Matteis, Serena, Scarpi, Emanuela, Granato, Anna Maria, Vespasiani-Gentilucci, Umberto, La Barba, Giuliano, Foschi, Francesco Giuseppe, Bandini, Erika, Ghetti, Martina, Marisi, Giorgia, Cravero, Paola, Gramantieri, Laura, Cucchetti, Alessandro, Ercolani, Giorgio, Santini, Daniele, Frassineti, Giovanni Luca, Faloppi, Luca, Scartozzi, Mario, Cascinu, Stefano, Casadei-Gardini, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6470641/
https://ncbi.nlm.nih.gov/pubmed/30917505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20061503
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