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Deletion of Osteopontin Enhances β(2)-Adrenergic Receptor-Dependent Anti-Fibrotic Signaling in Cardiomyocytes
Cardiac β(2)-adrenergic receptors (ARs) are known to inhibit collagen production and fibrosis in cardiac fibroblasts and myocytes. The β(2)AR is a Gs protein-coupled receptor (GPCR) and, upon its activation, stimulates the generation of cyclic 3′,5′-adenosine monophosphate (cAMP). cAMP has two effec...
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| 發表在: | Int J Mol Sci |
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| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
MDPI
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6470638/ https://ncbi.nlm.nih.gov/pubmed/30897705 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20061396 |
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