Deletion of Osteopontin Enhances β(2)-Adrenergic Receptor-Dependent Anti-Fibrotic Signaling in Cardiomyocytes

Cardiac β(2)-adrenergic receptors (ARs) are known to inhibit collagen production and fibrosis in cardiac fibroblasts and myocytes. The β(2)AR is a Gs protein-coupled receptor (GPCR) and, upon its activation, stimulates the generation of cyclic 3′,5′-adenosine monophosphate (cAMP). cAMP has two effec...

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Pubblicato in:Int J Mol Sci
Autori principali: Pollard, Celina M., Desimine, Victoria L., Wertz, Shelby L., Perez, Arianna, Parker, Barbara M., Maning, Jennifer, McCrink, Katie A., Shehadeh, Lina A., Lymperopoulos, Anastasios
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6470638/
https://ncbi.nlm.nih.gov/pubmed/30897705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20061396
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