Tenofovir Hot-Melt Granulation using Gelucire(®) to Develop Sustained-Release Vaginal Systems for Weekly Protection against Sexual Transmission of HIV

Hot-melt granulation is a technique used to obtain granules by dispersing a drug in polymers at a high temperature. Tenofovir, an antiretroviral drug with proven activity as a vaginal microbicide, was dispersed in melted Gelucire(®) (or a mixture of different Gelucire(®)) to obtain drug-loaded granu...

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Udgivet i:Pharmaceutics
Main Authors: Notario-Pérez, Fernando, Cazorla-Luna, Raúl, Martín-Illana, Araceli, Ruiz-Caro, Roberto, Peña, Juan, Veiga, María-Dolores
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6470605/
https://ncbi.nlm.nih.gov/pubmed/30897790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11030137
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