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Tenofovir Hot-Melt Granulation using Gelucire(®) to Develop Sustained-Release Vaginal Systems for Weekly Protection against Sexual Transmission of HIV
Hot-melt granulation is a technique used to obtain granules by dispersing a drug in polymers at a high temperature. Tenofovir, an antiretroviral drug with proven activity as a vaginal microbicide, was dispersed in melted Gelucire(®) (or a mixture of different Gelucire(®)) to obtain drug-loaded granu...
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| 發表在: | Pharmaceutics |
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| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
MDPI
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6470605/ https://ncbi.nlm.nih.gov/pubmed/30897790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11030137 |
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