Caffeic Acid Phenethyl Ester Rescues Pulmonary Arterial Hypertension through the Inhibition of AKT/ERK-Dependent PDGF/HIF-1α In Vitro and In Vivo

Pulmonary arterial hypertension (PAH) is characterized by pulmonary arterial proliferation and remodeling, resulting in a specific increase in right ventricle systolic pressure (RVSP) and, ultimately right ventricular failure. Recent studies have demonstrated that caffeic acid phenethyl ester (CAPE)...

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Gepubliceerd in:Int J Mol Sci
Hoofdauteurs: Cheng, Chin-Chang, Chi, Pei-Ling, Shen, Min-Ci, Shu, Chih-Wen, Wann, Shue-Ren, Liu, Chun-Peng, Tseng, Ching-Jiunn, Huang, Wei-Chun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6470604/
https://ncbi.nlm.nih.gov/pubmed/30909527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20061468
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