Intracellular Fe(2+) accumulation in endothelial cells and pericytes induces blood-brain barrier dysfunction in secondary brain injury after brain hemorrhage

After intracranial hemorrhage (ICH), iron is released from the hematoma and induces secondary brain injury. However, the detail effect of iron on blood-brain barrier (BBB) function is still unknown. We investigated whether hemoglobin (Hb), ferrous ammonium sulfate (FAS) or hemin which contains iron...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Imai, Takahiko, Iwata, Sena, Hirayama, Tasuku, Nagasawa, Hideko, Nakamura, Shinsuke, Shimazawa, Masamitsu, Hara, Hideaki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6470176/
https://ncbi.nlm.nih.gov/pubmed/30996325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42370-z
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