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Intracellular Fe(2+) accumulation in endothelial cells and pericytes induces blood-brain barrier dysfunction in secondary brain injury after brain hemorrhage

After intracranial hemorrhage (ICH), iron is released from the hematoma and induces secondary brain injury. However, the detail effect of iron on blood-brain barrier (BBB) function is still unknown. We investigated whether hemoglobin (Hb), ferrous ammonium sulfate (FAS) or hemin which contains iron...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Imai, Takahiko, Iwata, Sena, Hirayama, Tasuku, Nagasawa, Hideko, Nakamura, Shinsuke, Shimazawa, Masamitsu, Hara, Hideaki
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6470176/
https://ncbi.nlm.nih.gov/pubmed/30996325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42370-z
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