Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK–NF-κB signaling mediated inflammation

Macrophage-orchestrated, low-grade chronic inflammation plays a pivotal role in obesity and atherogenesis. However, the underlying regulatory mechanisms remain incompletely understood. Here, we identify major vault protein (MVP), the main component of unique cellular ribonucleoprotein particles, as...

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Published in:Nat Commun
Main Authors: Ben, Jingjing, Jiang, Bin, Wang, Dongdong, Liu, Qingling, Zhang, Yongjing, Qi, Yu, Tong, Xing, Chen, Lili, Liu, Xianzhong, Zhang, Yan, Zhu, Xudong, Li, Xiaoyu, Zhang, Hanwen, Bai, Hui, Yang, Qing, Ma, Junqing, Wiemer, Erik A. C., Xu, Yong, Chen, Qi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6470148/
https://ncbi.nlm.nih.gov/pubmed/30996248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09588-x
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