Novel CSF biomarkers in genetic frontotemporal dementia identified by proteomics

OBJECTIVE: To identify novel CSF biomarkers in GRN‐associated frontotemporal dementia (FTD) by proteomics using mass spectrometry (MS). METHODS: Unbiased MS was applied to CSF samples from 19 presymptomatic and 9 symptomatic GRN mutation carriers and 24 noncarriers. Protein abundances were compared...

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Udgivet i:Ann Clin Transl Neurol
Main Authors: van der Ende, Emma L., Meeter, Lieke H., Stingl, Christoph, van Rooij, Jeroen G. J., Stoop, Marcel P., Nijholt, Diana A. T., Sanchez‐Valle, Raquel, Graff, Caroline, Öijerstedt, Linn, Grossman, Murray, McMillan, Corey, Pijnenburg, Yolande A. L., Laforce, Robert, Binetti, Giuliano, Benussi, Luisa, Ghidoni, Roberta, Luider, Theo M., Seelaar, Harro, van Swieten, John C.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6469343/
https://ncbi.nlm.nih.gov/pubmed/31019994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.745
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