Acute canagliflozin treatment protects against in vivo myocardial ischemia–reperfusion injury in non-diabetic male rats and enhances endothelium-dependent vasorelaxation

BACKGROUND: The sodium–glucose cotransporter-2 (SGLT2) inhibitor canagliflozin has been shown to reduce major cardiovascular events in type 2 diabetic patients, with a pronounced decrease in hospitalization for heart failure (HF) especially in those with HF at baseline. These might indicate a potent...

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Bibliografiske detaljer
Udgivet i:J Transl Med
Main Authors: Sayour, Alex Ali, Korkmaz-Icöz, Sevil, Loganathan, Sivakkanan, Ruppert, Mihály, Sayour, Viktor Nabil, Oláh, Attila, Benke, Kálmán, Brune, Maik, Benkő, Rita, Horváth, Eszter Mária, Karck, Matthias, Merkely, Béla, Radovits, Tamás, Szabó, Gábor
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6469222/
https://ncbi.nlm.nih.gov/pubmed/30992077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-019-1881-8
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