Discovery and Optimization of nTZDpa as an Antibiotic Effective Against Bacterial Persisters

Conventional antibiotics are not effective in treating infections caused by drug-resistant or persistent nongrowing bacteria, creating a dire need for the development of new antibiotics. We report that the small molecule nTZDpa, previously characterized as a nonthiazolidinedione peroxisome prolifera...

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Detalhes bibliográficos
Publicado no:ACS Infect Dis
Main Authors: Kim, Wooseong, Steele, Andrew D., Zhu, Wenpeng, Csatary, Erika E., Fricke, Nico, Dekarske, Madeline M., Jayamani, Elamparithi, Pan, Wen, Kwon, Bumsup, Sinitsa, Isabelle F., Rosen, Jake L., Conery, Annie L., Fuchs, Beth Burgwyn, Vlahovska, Petia M., Ausubel, Frederick M., Gao, Huajian, Wuest, William M., Mylonakis, Eleftherios
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6468991/
https://ncbi.nlm.nih.gov/pubmed/30132650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.8b00161
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