Modafinil protects hippocampal neurons by suppressing excessive autophagy and apoptosis in mice with sleep deprivation

BACKGROUND AND PURPOSE: Sleep deprivation compromises learning and memory in both humans and animals, and can be reversed by administration of modafinil, a drug promoting wakefulness. Dysfunctional autophagy increases activation of apoptotic cascades, ultimately leading to increased neuronal death,...

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Veröffentlicht in:Br J Pharmacol
Hauptverfasser: Cao, Yin, Li, Qinglin, Liu, Lulu, Wu, Hui, Huang, Fei, Wang, Changhong, Lan, Yunyi, Zheng, Fang, Xing, Faping, Zhou, Qiang, Li, Qi, Shi, Hailian, Zhang, Beibei, Wang, Zhengtao, Wu, Xiaojun
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6468261/
https://ncbi.nlm.nih.gov/pubmed/30767208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14626
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