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The E3-ligases SCF(Ppa) and APC/C(Cdh1) co-operate to regulate CENP-A(CID) expression across the cell cycle
Centromere identity is determined by the specific deposition of CENP-A, a histone H3 variant localizing exclusively at centromeres. Increased CENP-A expression, which is a frequent event in cancer, causes mislocalization, ectopic kinetochore assembly and genomic instability. Proteolysis regulates CE...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6468245/ https://ncbi.nlm.nih.gov/pubmed/30753559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz060 |
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