A semi-synthetic neolignan derivative from dihydrodieugenol B selectively affects the bioenergetic system of Leishmania infantum and inhibits cell division

Leishmaniasis is a neglected disease that affects more than 12 million people, with a limited therapy. Plant-derived natural products represent a useful source of anti-protozoan prototypes. In this work, four derivatives were prepared from neolignans isolated from the Brazilian plant Nectandra leuca...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Amaral, Maiara, de Sousa, Fernanda S., Silva, Thais A. Costa, Junior, Andrés Jimenez G., Taniwaki, Noemi N., Johns, Deidre M., Lago, João Henrique G., Anderson, Edward A., Tempone, Andre G.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467890/
https://ncbi.nlm.nih.gov/pubmed/30992481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42273-z
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