Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment

The identity and unique capacity of cancer stem cells (CSC) to drive tumor growth and resistance have been challenged in brain tumors. Here we report that cells expressing CSC-associated cell membrane markers in Glioblastoma (GBM) do not represent a clonal entity defined by distinct functional prope...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Dirkse, Anne, Golebiewska, Anna, Buder, Thomas, Nazarov, Petr V., Muller, Arnaud, Poovathingal, Suresh, Brons, Nicolaas H. C., Leite, Sonia, Sauvageot, Nicolas, Sarkisjan, Dzjemma, Seyfrid, Mathieu, Fritah, Sabrina, Stieber, Daniel, Michelucci, Alessandro, Hertel, Frank, Herold-Mende, Christel, Azuaje, Francisco, Skupin, Alexander, Bjerkvig, Rolf, Deutsch, Andreas, Voss-Böhme, Anja, Niclou, Simone P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467886/
https://ncbi.nlm.nih.gov/pubmed/30992437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09853-z
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