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A PKD1L3 splicing variant in taste buds is not cleaved at the G protein-coupled receptor proteolytic site
Mutations in polycystin proteins PKD1 and TRPP2 lead to autosomal dominant polycystic kidney disease. These two proteins form a receptor-ion channel complex on primary cilia. PKD1 undergoes an autoproteolysis at the N terminal G-protein-coupled receptor proteolytic site (GPS), which is essential for...
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| Publicado no: | Biochem Biophys Res Commun |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6467730/ https://ncbi.nlm.nih.gov/pubmed/30928102 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2019.03.099 |
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