Targeted metabolomics identifies the cytochrome P450 monooxygenase eicosanoid pathway as a novel therapeutic target of colon tumorigenesis

Colon cancer is the third most common cancer and the second leading cause of cancer-related death in the United States, emphasizing the need for discovery of new cellular targets. Using a metabolomics approach, we report here that epoxygenated fatty acids (EpFA), which are eicosanoid metabolites pro...

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Vydáno v:Cancer Res
Hlavní autoři: Wang, Weicang, Yang, Jun, Edin, Matthew L., Wang, Yuxin, Luo, Ying, Wan, Debin, Yang, Haixia, Song, Chun-Qing, Xue, Wen, Sanidad, Katherine Z., Song, Mingyue, Bisbee, Heather A., Bradbury, Jennifer A., Nan, Guanjun, Zhang, Jianan, Shih, Pei-an Betty, Lee, Kin Sing Stephen, Minter, Lisa M., Kim, Daeyoung, Xiao, Hang, Liu, Jun-Yan, Hammock, Bruce D., Zeldin, Darryl C., Zhang, Guodong
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467714/
https://ncbi.nlm.nih.gov/pubmed/30803995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-3221
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