Replacement of the Thiosugar of Auranofin with Iodide Enhances the Anticancer Potency in a Mouse Model of Ovarian Cancer

[Image: see text] In recent years, a few successful attempts were made to repurpose the clinically approved antiarthritic gold drug, Auranofin (AF), as an anticancer agent. The present study shows that the iodido(triethylphosphine)gold(I) complex, (Et(3)PAuI hereafter)—an AF analogue where the thios...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Marzo, Tiziano, Massai, Lara, Pratesi, Alessandro, Stefanini, Matteo, Cirri, Damiano, Magherini, Francesca, Becatti, Matteo, Landini, Ida, Nobili, Stefania, Mini, Enrico, Crociani, Olivia, Arcangeli, Annarosa, Pillozzi, Serena, Gamberi, Tania, Messori, Luigi
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6466815/
https://ncbi.nlm.nih.gov/pubmed/30996813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00007
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