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Inhibition of PCSK9(D374Y)/LDLR Protein–Protein Interaction by Computationally Designed T9 Lupin Peptide
[Image: see text] The inhibition of the PCSK9/LDLR protein–protein interaction is a promising strategy for developing new hypocholesterolemic agents. Familial hypercholesterolemia is linked to specific PCSK9 mutations: the D374Y is the most potent gain-of-function (GOF) PCSK9 mutation among clinical...
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| Publicado no: | ACS Med Chem Lett |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2018
|
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6466515/ https://ncbi.nlm.nih.gov/pubmed/30996774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00464 |
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