Surrogacy of Time to Progression for Overall Survival in Advanced Hepatocellular Carcinoma Treated with Systemic Therapy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Time to progression (TTP) is widely used as the endpoint in early-phase trials of advanced hepatocellular carcinoma (HCC). However, the relevance of using TTP as a surrogate marker for overall survival (OS) in pivotal trials remains uncertain. The PubMed database and ASCO Meeting Library were search...

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Detalhes bibliográficos
Publicado no:Liver Cancer
Main Authors: Terashima, Takeshi, Yamashita, Tatsuya, Toyama, Tadashi, Arai, Kuniaki, Kawaguchi, Kazunori, Kitamura, Kazuya, Yamashita, Taro, Sakai, Yoshio, Mizukoshi, Eishiro, Honda, Masao, Kaneko, Shuichi
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2019
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6465721/
https://ncbi.nlm.nih.gov/pubmed/31019903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000489505
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