Blocking TBK1 alleviated radiation-induced pulmonary fibrosis and epithelial-mesenchymal transition through Akt-Erk inactivation

As a common serious complication of thoracic radiotherapy, radiation-induced pulmonary fibrosis (RIPF) severely limits radiation therapy approaches. Epithelial–mesenchymal transition (EMT) is a direct contributor to the fibroblast pool during fibrogenesis, and prevention of EMT is considered an effe...

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Detalhes bibliográficos
Publicado no:Exp Mol Med
Main Authors: Qu, Hongjin, Liu, Lei, Liu, Zhe, Qin, Hongran, Liao, Zebin, Xia, Penglin, Yang, Yanyong, Li, Bailong, Gao, Fu, Cai, Jianming
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6465273/
https://ncbi.nlm.nih.gov/pubmed/30988282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-019-0240-4
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