Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss

Mitogen-activated protein kinases (MAPK) such as p38 and the c-Jun N-terminal kinases (JNKs) are activated during the cellular response to stress signals. Their activity is regulated by the MAPK-phosphatase 1 (DUSP1), a key component of the anti-inflammatory response. Stress kinases are well-describ...

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Veröffentlicht in:eLife
Hauptverfasser: Celaya, Adelaida M, Sánchez-Pérez, Isabel, Bermúdez-Muñoz, Jose M, Rodríguez-de la Rosa, Lourdes, Pintado-Berninches, Laura, Perona, Rosario, Murillo-Cuesta, Silvia, Varela-Nieto, Isabel
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2019
Schlagworte:
Human Biology and Medicine
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6464786/
https://ncbi.nlm.nih.gov/pubmed/30938680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.39159
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