Betaine-homocysteine S-methyltransferase deficiency causes increased susceptibility to noise-induced hearing loss associated with plasma hyperhomocysteinemia

Betaine-homocysteine S-methyltransferases (BHMTs) are methionine cycle enzymes that remethylate homocysteine; hence, their malfunction leads to hyperhomocysteinemia. Epidemiologic and experimental studies have revealed a correlation between hyperhomocysteinemia and hearing loss. Here, we have studie...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Partearroyo, Teresa, Murillo-Cuesta, Silvia, Vallecillo, Néstor, Bermúdez-Muñoz, Jose M., Rodríguez-de la Rosa, Lourdes, Mandruzzato, Giacomo, Celaya, Adelaida M., Zeisel, Steven H., Pajares, María A., Varela-Moreiras, Gregorio, Varela-Nieto, Isabel
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6463923/
https://ncbi.nlm.nih.gov/pubmed/30753104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201801533R
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