Catestatin Inhibits Obesity-Induced Macrophage Infiltration and Inflammation in the Liver and Suppresses Hepatic Glucose Production, Leading to Improved Insulin Sensitivity

The activation of Kupffer cells (KCs) and monocyte-derived recruited macrophages (McMΦs) in the liver contributes to obesity-induced insulin resistance and type 2 diabetes. Mice with diet-induced obesity (DIO mice) treated with chromogranin A peptide catestatin (CST) showed several positive results....

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Ying, Wei, Mahata, Sumana, Bandyopadhyay, Gautam K., Zhou, Zhenqi, Wollam, Joshua, Vu, Jessica, Mayoral, Rafael, Chi, Nai-Wen, Webster, Nicholas J.G., Corti, Angelo, Mahata, Sushil K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2018
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6463753/
https://ncbi.nlm.nih.gov/pubmed/29432123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-0788
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