Deep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer

Our understanding of genomic heterogeneity in lung cancer is largely based on the analysis of early-stage surgical specimens. Here we used endoscopic sampling of paired primary and intrathoracic metastatic tumors from 11 lung cancer patients to map genomic heterogeneity inoperable lung cancer with d...

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Publicado no:Oncogene
Main Authors: Leong, Tracy L., Gayevskiy, Velimir, Steinfort, Daniel P., De Massy, Marc R., Gonzalez-Rajal, Alvaro, Marini, Kieren D., Stone, Emily, Chin, Venessa, Havryk, Adrian, Plit, Marshall, Irving, Louis B., Jennings, Barton R., McCloy, Rachael A., Jayasekara, W. Samantha N., Alamgeer, Muhammad, Boolell, Vishal, Field, Andrew, Russell, Prudence A., Kumar, Beena, Gough, Daniel J., Szczepny, Anette, Ganju, Vinod, Rossello, Fernando J., Cain, Jason E., Papenfuss, Anthony T., Asselin-Labat, Marie-Liesse, Cowley, Mark J., Watkins, D. Neil
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462862/
https://ncbi.nlm.nih.gov/pubmed/30348992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0536-1
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