Nuclear receptor gene polymorphisms and warfarin dose requirements in the Quebec Warfarin Cohort

Warfarin is primarily metabolized by cytochrome 2C9, encoded by gene CYP2C9. Here, we investigated whether variants in nuclear receptor genes which regulate the expression of CYP2C9 are associated with warfarin response. We used data from 906 warfarin users from the Quebec Warfarin Cohort (QWC) and...

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Detalhes bibliográficos
Publicado no:Pharmacogenomics J
Main Authors: Shahabi, Payman, Lamothe, Félix, Dumas, Stéphanie, Rouleau-Mailloux, Étienne, Feroz Zada, Yassamin, Provost, Sylvie, Asselin, Geraldine, Mongrain, Ian, Valois, Diane, Gaulin Marion, Marie-Josée, Lemieux Perreault, Louis-Philippe, Perreault, Sylvie, Dubé, Marie-Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462825/
https://ncbi.nlm.nih.gov/pubmed/29298995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41397-017-0005-1
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