Modulation of Gut Microbiota Composition by Serotonin Signaling Influences Intestinal Immune Response and Susceptibility to Colitis

BACKGROUND & AIMS: Serotonin (5-hydroxytryptamine [5-HT]) is synthesized mainly within enterochromaffin (EC) cells in the gut, and tryptophan hydroxylase 1 (Tph1) is the rate-limiting enzyme for 5-HT synthesis in EC cells. Accumulating evidence suggests the importance of gut microbiota in intest...

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Detalles Bibliográficos
Publicado en:Cell Mol Gastroenterol Hepatol
Main Authors: Kwon, Yun Han, Wang, Huaqing, Denou, Emmanuel, Ghia, Jean-Eric, Rossi, Laura, Fontes, Michelle E., Bernier, Steve P., Shajib, Md. Sharif, Banskota, Suhrid, Collins, Stephen M., Surette, Michael G., Khan, Waliul I.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2019
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462823/
https://ncbi.nlm.nih.gov/pubmed/30716420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2019.01.004
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