Doxycycline reduces MMP-2 activity and inhibits invasion of 12Z epithelial endometriotic cells as well as MMP-2 and -9 activity in primary endometriotic stromal cells in vitro

BACKGROUND: Matrix metalloproteinases (MMPs), especially the gelatinases MMP-2 and MMP-9, play a crucial role in the pathogenesis of endometriosis by enabling invasion. Doxycycline is a well-tolerated antibiotic and a potent MMP-inhibitor in subantimicrobial doses. METHODS: Gelatin zymography and ac...

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Bibliografische gegevens
Gepubliceerd in:Reprod Biol Endocrinol
Hoofdauteurs: Samartzis, Eleftherios P., Fink, Daniel, Stucki, Manuel, Imesch, Patrick
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2019
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462312/
https://ncbi.nlm.nih.gov/pubmed/30981279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12958-019-0481-z
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