Salmonella SiiE prevents an efficient humoral immune memory by interfering with IgG(+) plasma cell persistence in the bone marrow

Serum IgG, which is mainly generated from IgG-secreting plasma cells in the bone marrow (BM), protects our body against various pathogens. We show here that the protein SiiE of Salmonella is both required and sufficient to prevent an efficient humoral immune memory against the pathogen by selectivel...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Männe, Christian, Takaya, Akiko, Yamasaki, Yuzuru, Mursell, Mathias, Hojyo, Shintaro, Wu, Tsung-Yen, Sarkander, Jana, McGrath, Mairi A., Cornelis, Rebecca, Hahne, Stefanie, Cheng, Qingyu, Kawamoto, Tadafumi, Hiepe, Falk, Kaufmann, Stefan H. E., Yamamoto, Tomoko, Radbruch, Andreas, Tokoyoda, Koji
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462062/
https://ncbi.nlm.nih.gov/pubmed/30910977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818242116
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