Salmonella SiiE prevents an efficient humoral immune memory by interfering with IgG(+) plasma cell persistence in the bone marrow

Serum IgG, which is mainly generated from IgG-secreting plasma cells in the bone marrow (BM), protects our body against various pathogens. We show here that the protein SiiE of Salmonella is both required and sufficient to prevent an efficient humoral immune memory against the pathogen by selectivel...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Männe, Christian, Takaya, Akiko, Yamasaki, Yuzuru, Mursell, Mathias, Hojyo, Shintaro, Wu, Tsung-Yen, Sarkander, Jana, McGrath, Mairi A., Cornelis, Rebecca, Hahne, Stefanie, Cheng, Qingyu, Kawamoto, Tadafumi, Hiepe, Falk, Kaufmann, Stefan H. E., Yamamoto, Tomoko, Radbruch, Andreas, Tokoyoda, Koji
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462062/
https://ncbi.nlm.nih.gov/pubmed/30910977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818242116
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