Expression of the oxygen-sensitive transcription factor subunit HIF-1α in patients suffering from secondary Raynaud syndrome

Anti-ischemic therapy remains a challenge due to the complexity of hypoxia response pathways. Hypoxia-inducible factor (HIF)-1 is a heterodimer transcription factor consisting of 2 subunits, HIF-1α and HIF-1β. Hypoxia-dependent activation of HIF-1α regulates cellular O(2) homeostasis. Raynaud syndro...

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Pubblicato in:Acta Pharmacol Sin
Autori principali: Heger, Lukas Andreas, Kerber, Mark, Hortmann, Marcus, Robinson, Samuel, Mauler, Maximilian, Stallmann, Daniela, Duerschmied, Daniel, Bode, Christoph, Hehrlein, Christoph, Ahrens, Ingo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461843/
https://ncbi.nlm.nih.gov/pubmed/29991707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-018-0055-1
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