NDR2 kinase contributes to cell invasion and cytokinesis defects induced by the inactivation of RASSF1A tumor-suppressor gene in lung cancer cells

BACKGROUND: RASSF1A, a tumor suppressor gene, is frequently inactivated in lung cancer leading to a YAP-dependent epithelial-mesenchymal transition (EMT). Such effects are partly due to the inactivation of the anti-migratory RhoB GTPase via the inhibitory phosphorylation of GEF-H1, the GDP/GTP excha...

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Vydáno v:J Exp Clin Cancer Res
Hlavní autoři: Keller, Maureen, Dubois, Fatéméh, Teulier, Sylvain, Martin, Alexandre P. J., Levallet, Jérôme, Maille, Elodie, Brosseau, Solenn, Elie, Nicolas, Hergovich, Alexander, Bergot, Emmanuel, Camonis, Jacques, Zalcman, Gérard, Levallet, Guénaëlle
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461807/
https://ncbi.nlm.nih.gov/pubmed/30979377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1145-8
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