Effects of SLCO1B1 and GATM gene variants on rosuvastatin-induced myopathy are unrelated to high plasma exposure of rosuvastatin and its metabolites

Myotoxicity is a significant factor contributing to the poor adherence and reduced effectiveness in the treatment of statins. Genetic variations and high drug plasma exposure are considered as critique causes for statin-induced myopathy (SIM). This study aims to explore the sequential influences of...

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Vydáno v:Acta Pharmacol Sin
Hlavní autoři: Bai, Xue, Zhang, Bin, Wang, Ping, Wang, Guan-lei, Li, Jia-li, Wen, Ding-sheng, Long, Xing-zhen, Sun, Hong-shuo, Liu, Yi-bin, Huang, Min, Zhong, Shi-long
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461793/
https://ncbi.nlm.nih.gov/pubmed/29950617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-018-0013-y
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