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Asiatic acid enhances intratumor delivery and the antitumor effect of pegylated liposomal doxorubicin by reducing tumor-stroma collagen

Tumor-targeted drug delivery systems (Tt-DDSs) are proposed as a promising strategy for cancer care. However, the dense collagen network in tumors stroma significantly reduces the penetration and efficacy of Tt-DDS. In order to investigate the effect of asiatic acid (AA) on antitumor effect of pegyl...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Acta Pharmacol Sin
Hauptverfasser: Fang, Luo, Kong, Si-si, Zhong, Li-ke, Wang, Can-ming, Liu, Yu-jia, Ding, Hai-ying, Sun, Jiao, Zhang, Yi-wen, Li, Fan-zhu, Huang, Ping
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461755/
https://ncbi.nlm.nih.gov/pubmed/29921887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-018-0038-2
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