Tumor-Derived Extracellular Vesicles Require β1 Integrins to Promote Anchorage-Independent Growth

The β1 integrins, known to promote cancer progression, are abundant in extracellular vesicles (EVs). We investigated whether prostate cancer (PrCa) EVs affect anchorage-independent growth and whether β1 integrins are required for this effect. Specifically using a cell-line-based genetic rescue and a...

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Veröffentlicht in:iScience
Hauptverfasser: DeRita, Rachel M., Sayeed, Aejaz, Garcia, Vaughn, Krishn, Shiv Ram, Shields, Christopher D., Sarker, Srawasti, Friedman, Andrea, McCue, Peter, Molugu, Sudheer Kumar, Rodeck, Ulrich, Dicker, Adam P., Languino, Lucia R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461598/
https://ncbi.nlm.nih.gov/pubmed/30981115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.03.022
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