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Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis
Epithelial barrier loss is a driver of intestinal and systemic diseases. Myosin light chain kinase (MLCK) is a key effector of barrier dysfunction and a potential therapeutic target, but enzymatic inhibition has unacceptable toxicities. Here, we show that a unique domain within the MLCK splice-varia...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Nat Med |
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| Prif Awduron: | , , , , , , , , , , , , , , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2019
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6461392/ https://ncbi.nlm.nih.gov/pubmed/30936544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-019-0393-7 |
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