Recombinant Marburg viruses containing mutations in the IID region of VP35 prevent inhibition of Host immune responses()

Previous in vitro studies have demonstrated that Ebola and Marburg virus (EBOV and MARV) VP35 antagonize the host cell immune response. Moreover, specific mutations in the IFN inhibitory domain (IID) of EBOV and MARV VP35 that abrogate their interaction with virus-derived dsRNA, lack the ability to...

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Publicado no:Virology
Main Authors: Albariño, César G., Guerrero, Lisa Wiggleton, Spengler, Jessica R., Uebelhoer, Luke S., Chakrabarti, Ayan K., Nichol, Stuart T., Towner, Jonathan S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461211/
https://ncbi.nlm.nih.gov/pubmed/25531184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2014.12.002
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