Schizophrenia Polygenic Risk Score as a Predictor of Antipsychotic Efficacy in First Episode Psychosis

OBJECTIVE: Pharmacogenomic studies of antipsychotics have typically examined effects of individual polymorphisms; by contrast, polygenic risk scores (PRS) derived from genome-wide association studies (GWAS) can quantify the influence of thousands of common alleles of small effect in a single measure...

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Vydáno v:Am J Psychiatry
Hlavní autoři: Zhang, Jian-Ping, Robinson, Delbert, Yu, Jin, Gallego, Juan, Wolfgang Fleischhacker, W., Kahn, Rene S., Crespo-Facorro, Benedicto, Vazquez-Bourgon, Javier, Kane, John M., Malhotra, Anil K., Lencz, Todd
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461047/
https://ncbi.nlm.nih.gov/pubmed/30392411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1176/appi.ajp.2018.17121363
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