Progerin accelerates atherosclerosis by inducing endoplasmic reticulum stress in vascular smooth muscle cells

Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by progerin, a mutant lamin A variant. HGPS patients display accelerated aging and die prematurely, typically from atherosclerosis complications. Recently, we demonstrated that progerin‐driven vascular smooth muscle cell (...

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Publicat a:EMBO Mol Med
Autors principals: Hamczyk, Magda R, Villa‐Bellosta, Ricardo, Quesada, Víctor, Gonzalo, Pilar, Vidak, Sandra, Nevado, Rosa M, Andrés‐Manzano, María J, Misteli, Tom, López‐Otín, Carlos, Andrés, Vicente
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6460349/
https://ncbi.nlm.nih.gov/pubmed/30862662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201809736
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