Utility of Neuronal-Derived Exosomes to Examine Molecular Mechanisms That Affect Motor Function in Patients With Parkinson Disease: A Secondary Analysis of the Exenatide-PD Trial

IMPORTANCE: Exenatide, a glucagon-like peptide 1 agonist used in type 2 diabetes, was recently found to have beneficial effects on motor function in a randomized, placebo-controlled trial in Parkinson disease (PD). Accumulating evidence suggests that impaired brain insulin and protein kinase B (Akt)...

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Detalhes bibliográficos
Publicado no:JAMA Neurol
Main Authors: Athauda, Dilan, Gulyani, Seema, Karnati, Hanuma kumar, Li, Yazhou, Tweedie, David, Mustapic, Maja, Chawla, Sahil, Chowdhury, Kashfia, Skene, Simon S., Greig, Nigel H., Kapogiannis, Dimitrios, Foltynie, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2019
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6459135/
https://ncbi.nlm.nih.gov/pubmed/30640362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2018.4304
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