Assessment of mGluR5 KO mice under conditions of low stress using a rodent touchscreen apparatus reveals impaired behavioural flexibility driven by perseverative responses

Genetic and pharmacological manipulations targeting metabotropic glutamate receptor 5 (mGluR5) affect performance in behavioural paradigms that depend on cognitive flexibility. Many of these studies involved exposing mice to highly stressful conditions including electric foot shocks or water immersi...

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Detalhes bibliográficos
Publicado no:Mol Brain
Main Authors: Lim, Jisoo, Kim, Eosu, Noh, Hyun Jong, Kang, Shinwon, Phillips, Benjamin U., Kim, Dong Goo, Bussey, Timothy J., Saksida, Lisa, Heath, Christopher J., Kim, Chul Hoon
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6458840/
https://ncbi.nlm.nih.gov/pubmed/30971312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-019-0441-8
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