CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110β and predicts poor prognosis

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide because of rapid progression and high incidence of metastasis or recurrence. Accumulating evidence shows that CD73-expressing tumor cell is implicated in development of several types of cancer. However, th...

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Gepubliceerd in:J Hematol Oncol
Hoofdauteurs: Ma, Xiao-Lu, Shen, Min-Na, Hu, Bo, Wang, Bei-Li, Yang, Wen-Jing, Lv, Li-Hua, Wang, Hao, Zhou, Yan, Jin, An-Li, Sun, Yun-Fan, Zhang, Chuan-Yan, Qiu, Shuang-Jian, Pan, Bai-Shen, Zhou, Jian, Fan, Jia, Yang, Xin-Rong, Guo, Wei
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2019
Onderwerpen:
Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6458749/
https://ncbi.nlm.nih.gov/pubmed/30971294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-019-0724-7
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