Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition

Lung cancer is the leading cause of cancer-related deaths worldwide. Tumor suppressor genes remain to be systemically identified for lung cancer. Through the genome-wide screening of tumor-suppressive transcription factors, we demonstrate here that GATA4 functions as an essential tumor suppressor in...

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Publicado en:Nat Commun
Autores principales: Gao, Lei, Hu, Yong, Tian, Yahui, Fan, Zhenzhen, Wang, Kun, Li, Hongdan, Zhou, Qian, Zeng, Guandi, Hu, Xin, Yu, Lei, Zhou, Shiyu, Tong, Xinyuan, Huang, Hsinyi, Chen, Haiquan, Liu, Qingsong, Liu, Wanting, Zhang, Gong, Zeng, Musheng, Zhou, Guangbiao, He, Qingyu, Ji, Hongbin, Chen, Liang
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6458308/
https://ncbi.nlm.nih.gov/pubmed/30971692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09295-7
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