SLPI Inhibits ATP-Mediated Maturation of IL-1β in Human Monocytic Leukocytes: A Novel Function of an Old Player

Interleukin-1β (IL-1β) is a potent, pro-inflammatory cytokine of the innate immune system that plays an essential role in host defense against infection. However, elevated circulating levels of IL-1β can cause life-threatening systemic inflammation. Hence, mechanisms controlling IL-1β maturation and...

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Dettagli Bibliografici
Pubblicato in:Front Immunol
Autori principali: Zakrzewicz, Anna, Richter, Katrin, Zakrzewicz, Dariusz, Siebers, Kathrin, Damm, Jelena, Agné, Alisa, Hecker, Andreas, McIntosh, J. Michael, Chamulitrat, Walee, Krasteva-Christ, Gabriela, Manzini, Ivan, Tikkanen, Ritva, Padberg, Winfried, Janciauskiene, Sabina, Grau, Veronika
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6458293/
https://ncbi.nlm.nih.gov/pubmed/31019507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00664
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