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The free energy landscape of the oncogene protein E7 of human papillomavirus type 16 reveals a complex interplay between ordered and disordered regions

When present, structural disorder makes it very challenging to characterise the conformational properties of proteins. This is particularly the case of proteins, such as the oncogene protein E7 of human papillomavirus type 16, which contain both ordered and disordered domains, and that can populate...

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Publicado en:Sci Rep
Autores principales: Kukic, Predrag, Lo Piccolo, Giuseppe Mattia, Nogueira, Marcela O., Svergun, Dmitri I., Vendruscolo, Michele, Felli, Isabella C., Pierattelli, Roberta
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6456579/
https://ncbi.nlm.nih.gov/pubmed/30967564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41925-4
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