Pirfenidone inhibits epidural scar fibroblast proliferation and differentiation by regulating TGF-β1-induced Smad-dependent and -independent pathways

Epidural fibrosis causes serious complications in patients who have undergone laminectomy. Pirfenidone is an effective antifibrotic agent but its effect on epidural fibrosis remains unclear. In this study, we aimed to investigate the effect of pirfenidone on epidural fibrosis and to evaluate its mec...

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Publicat a:Am J Transl Res
Autors principals: Shi, Kun, Wang, Fengzhen, Xia, Jihua, Zuo, Bangjie, Wang, Zhaohong, Cao, Xiaojian
Format: Artigo
Idioma:Inglês
Publicat: e-Century Publishing Corporation 2019
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6456526/
https://ncbi.nlm.nih.gov/pubmed/30972185
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