FoxO6-mediated IL-1β induces hepatic insulin resistance and age-related inflammation via the TF/PAR2 pathway in aging and diabetic mice

FoxO has been proposed to play a role in the promotion of insulin resistance, and inflammation. FoxO is a pro-inflammatory transcription factor that is a key mediator of generation of inflammatory cytokines such as IL-1β in the liver. However, the detailed association of FoxO6 with insulin resistanc...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Redox Biol
Main Authors: Kim, Dae Hyun, Lee, Bonggi, Lee, Jaewon, Kim, Mi Eun, Lee, Jun Sik, Chung, Jae Heun, Yu, Byung Pal, Dong, H. Henry, Chung, Hae Young
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2019
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6454229/
https://ncbi.nlm.nih.gov/pubmed/30974318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101184
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